Paget’s Disease causes bones too soften due to over activation of osteoclasts. Osteoclasts are responsible for breaking down bone. In response to this the body attempts to quickly lay down new bone. Which causes enlargement of the bone, typically the spine, skull and long bones are most affected.
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Brief overview of the episode:
Paget’s Disease is a rare bone disease that affects less than 1% of the population. There is over activation of osteoclasts (which break down bone). This result in the body trying to quickly rebuild build bone. However, the over response causes the new bone to soft and enlarged. This process is known as rapid isolated bone growth.
The good news is this disease is very rare, affecting less than 1% of the population, and in most cases is highly manageable. The prevalence is 3:2 men to women and is more common as we age.
Symptoms include pain in bones and joints, headache, hearing impairment, enlarged bones, bowing bones, numbness & tingling, difficulty bending over and fractures. Most commonly the long bones, spine and skull are impacted.
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Dr. Mike Pascoe Interview: Episode 12